Historical background of drug design and discovery, drug-receptor interactions and bond types involved in these interactions, the role of water/lipid solubility in binding, importance of stereochemistry in drug action, conformational flexibility, rigid analogs, importance of structure-activity relationships for new drug design and the role of acidity-basicity in drug effect, approaches used for the definition of lead compounds, design based on target macromolecules, endogenous molecules, analogue design, combinatorial chemistry, pharmacophore definition, lead compound modification and optimization, prediction of lipophilicity, ionization and steric parameters, pro drug design, drug targeting and soft drug design, the drug design based on enzymes, enzyme inhibitors, toxic effects due to functional groups and their corrections, examples of successful applications for rational drug design are the main topics.
- Teacher: Tanem Garanti