Crisis of Modernism and its concepts; their transformations: the holistic way of thinking in science, art and culture; their sociological, psychological and political results; their reflections on architecture; understanding and interpretation of this interactive process through new paradigms; hermeneutics and criticism; spatial interpretation from an epistemological perspective will be discussed according to the ideas and arguments of contemporary philosophers, sociologists and psychologists. Some philosophers and social scientists on epistemology who have contributions on the ideas of architectural configuration are examined within a post-structural approach. Besides, emphasis is given on some paradigmatic terms, such as narrative inquiry, systems way of thinking as an extension of the web of life, reality as possibility, which are the driving forces of new approaches in design research issues.