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In this course, students will learn about fundamental molecular biology laboratory techniques and will use those techniques to carry out experiments which theoretically coincide with topics studied in MBGE401 – Molecular Biology II. Therefore, students should not take this lab course unless they have taken MBGE401 or are currently taking it. Experiments/techniques that will be discussed and carried out are; the construction and cloning of recombinant DNA, DNA fingerprinting via Southern Blotting, and CRISPR. Additionally, cell lines will be used to discuss and carry out DNA and RNA extractions, cytotoxicity assays like LDH assays and protein extractions and protein concentration assays.
- Teacher: Peyman Ince
- Teacher: Deran Erdengiz
The complexities of the causes and the different types of cells that give rise to this disease have underscored the need for a better understanding of the basic biology of cancer; therefore, this course aims to provide a comprehensive overview of the biology and pathology of cancer. The course mainly focuses on the genetics and the molecular basis of cancer. The courses explores the role of mutations in cancer cells, and how they lead to the dysregulation of essential biological properties like programmed cell death, cell proliferation and differentiation. Furthermore, the influence of environmental factors in cancer susceptibility and comparisons of the classic treatment methods with newer treatment strategies like targeted therapies are elucidated.
MCLE572 THEORY OF MACHINES (3, 0) 3, ECTS: 8
The
course presents the basic mathematical theory of machines and focuses on the
principles of analysis and design of mechanisms and machines; together with
kinematic and dynamic analysis of linkages, gearing and gear train analysis.
The course coverage includes: Introduction to basic concepts; degree of
freedom, Grübler’s equation, classification of mechanisms; kinematic inversion,
enumeration; joint variables, loop closure equations; position, velocity and acceleration
analysis of mechanisms by graphical and analytical methods; four link
mechanisms; Grashof’s Rule, dead center positions, transmission angle,
mechanical advantage, body guidance, two and three position synthesis;
slider-crank mechanism; gears, simple and planetary gear trains; static and
dynamic force analysis. Students are required to complete and present a real
life design project and submit a formal project report.