Search results: 1929
The complexities of the causes and the different types of cells that give rise to this disease have underscored the need for a better understanding of the basic biology of cancer; therefore, this course aims to provide a comprehensive overview of the biology and pathology of cancer. The course mainly focuses on the genetics and the molecular basis of cancer. The courses explores the role of mutations in cancer cells, and how they lead to the dysregulation of essential biological properties like programmed cell death, cell proliferation and differentiation. Furthermore, the influence of environmental factors in cancer susceptibility and comparisons of the classic treatment methods with newer treatment strategies like targeted therapies are elucidated.
- Teacher: Cicek TopCu
Bakteriler, dünyadaki en basit yaşam formları arasında kabul edilir. Yine de, yaşam döngülerinin her sürecini, bölümlendirme yardımı olmadan tek bir hücre içinde yürüttükleri karmaşık ve zarif doğa şaşırtıcıdır. Bu derste, bakteri ve bakteriyofajlar tarafından kullanılan moleküler olayları ve stratejileri etraflıca inceleyeceğiz. Daha sonra bu organizmaların herhangi bir ortama nasıl uyum sağlayabildiğini ve tepki verebildiğini anlamak için bu bilgiyi vahşi doğadaki bakteriyel davranışlara uygulayacağız. / Description: Bacteria are considered to be amongst the simplest forms of life on earth. Yet the intricate and exquisite nature in which they conduct each process of their lifecycle within a single cell, without the aid of compartmentalization, is staggering. In this course, we will thoroughly examine the molecular events and strategies employed by bacteria and bacteriophages. We will then apply this knowledge to bacterial behaviour in the wild to understand how these organisms can adapt and respond to any given environment.
- Teacher: Ibrahim Ahmed
- Teacher: Mustafa Dagbasi
- Teacher: Berke EyyamoGlu
- Teacher: Ali Shefik
- Teacher: Berke EyyamoGlu
- Teacher: Vahid khojasteh
- Teacher: Mohammadreza Odumi
The main aim of this course is to enhance the understanding of thermodynamics principles and their relevance to the problems of humankind. The course provides the students with experience in applying thermodynamic principles to predict physical phenomena and to solve engineering problems. The course starts with fundamental definitions of related concepts to build up the unique vocabulary necessary in the course. The course continues with a quick introduction to the fundamental laws which are zeroth, first, second and third law of thermodynamics. The course continues with their applications to the common engineering problems such as steady flow device analysis, unsteady problem analysis and thermal system analysis.
The objective of this course is to provide students with a solid grounding in the classical and modern theories of convective heat and fluid flows. The emphasis is on both the laminar and turbulent boundary-layer heat and fluid flows. During the course laminar and turbulent heat transfer for flow in ducts will be discussed and the foundation of statistical theory of turbulence will be examined. Also, the problem of turbulent boundary layer flow over a flat plate in the presence of heat transfer will be described. Finally, the problem of heat transfer by natural convection for both laminar and turbulent boundary layer flow over a vertical hot wall will be described.
MCLE572 THEORY OF MACHINES (3, 0) 3, ECTS: 8
The
course presents the basic mathematical theory of machines and focuses on the
principles of analysis and design of mechanisms and machines; together with
kinematic and dynamic analysis of linkages, gearing and gear train analysis.
The course coverage includes: Introduction to basic concepts; degree of
freedom, Grübler’s equation, classification of mechanisms; kinematic inversion,
enumeration; joint variables, loop closure equations; position, velocity and acceleration
analysis of mechanisms by graphical and analytical methods; four link
mechanisms; Grashof’s Rule, dead center positions, transmission angle,
mechanical advantage, body guidance, two and three position synthesis;
slider-crank mechanism; gears, simple and planetary gear trains; static and
dynamic force analysis. Students are required to complete and present a real
life design project and submit a formal project report.
This course introduces some popular molecular graphics systems that allow for the visualization, animation, editing, and publication-quality imagery of proteins. It focuses on hands-on experience in the classroom and builds solid skills in visually investigating the 3D molecular structures of proteins and their interactions with each other and with ligands such as substrates and drugs. The course also explores the importance of protein sequence and structure alignment programs in revealing evolutionary relationships between proteins. Finally, it emphasizes the use of computational tools for predicting the effects of amino acid substitutions on protein structure and function as well as classifying mutations as deleterious or benign.
- Teacher: Bashir Ahmad
This course provides an overview on the role of microbiome in human health and disease. It focuses on conceptual framework and technologies for understanding how microbiome, particularly gut microbiome impact human health and well-being. Topics covered include the concept of human superorganism, microbiome and human adaptation/evolution, effects of nutrition on human microbiota, ecological principles of microbiomes, systems thinking and approaches for working on human microbiome, bioinformatics and statistics tool kits for human microbiome research; research strategy and experimental/trial design in microbiome study, from correlation to causality of human microbiome in chronic diseases, nutrition and gut microbiome, food processing and gut microbiome. The following topics are also included; microbiome in medicine Intergenerational, vertical transmission of human microbiomes, horizontal transfer of human microbiomes, microbiome and human society, microbiome and human-nature relationship.
- Teacher: Bashir Ahmad
- Teacher: Nagat Balaman
This course is designed to provide students a basic knowledge about inherited metabolic disorders. The course aims to gain the students the knowledge necessary to understand the cause and effect relationship between genetic mutations and molecular basis of diseases. The course covers all clinically important metabolic pathways such as amino acid, nucleotide, urea cycle disorders, galactosemia/galactosuria, glycogen and lysosomal storage diseases. Phenylketonuria (PKU), Maple Syrup Disease, Ornithine Transcarbamoylase Deficiency, UDP-Galactose-4 Epimerase Deficiency (GALE), Lesch-Nyhan Syndrome, von Gierke’s Disease, McArdle’s Disease, Tays-Sachs Disease are included in this course. This course also focuses on the analytical and diagnostic tools using to reveal molecular markers of these diseases. This course consists of lectures enriched with cases and case discussion.
- Teacher: Ali Alkaleel
- Teacher: Halil Resmi